贝那普利联合阿托伐他汀治疗慢性心力衰竭的价值研究

Therapeutic value of benazepril combined with atorvastatin for chronic heart failure

目的分析贝那普利联合阿托伐他汀治疗慢性心力衰竭的价值。方法抽取2019年4月至2022年4月南阳医学高等专科学校第一附属医院收治的慢性心力衰竭患者116例,按随机数字表法分为观察组与对照组,每组58例。对照组采用贝那普利治疗,观察组采用贝那普利联合阿托伐他汀治疗。比较两组治疗效果、心脏超声指标[左室射血分数(LVEF)、左心室舒张末期直径(LVEDD)、左心室收缩末期直径(LVESD)]、心电图水平[QRS波群(QRS)、QT离散度(QTd)、校正QT离散度(QTcd)]、心率变异性[窦性心律R-R间期总体标准差(SDNN)、相邻正常R-R间期差值均方根(rMSSD)、连续5 min正常R-R间期均值标准差(SDANN)]、6 min步行试验距离及炎症因子[超敏-C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平。结果观察组总有效率(94.83%,55/58)高于对照组(79.31%,46/58),P<0.05。治疗后,观察组LVEF高于对照组,LVEDD、LVESD低于对照组(P<0.05)。治疗后,观察组QRs、QTd、QTcd低于对照组(P<0.05),SDNN、rMSSD、SDANN高于对照组(P<0.05)。治疗后,观察组6 min步行试验距离长于对照组(P<0.05)。治疗后,观察组hs-CRP、IL-6、TNF-α水平低于对照组(P<0.05)。结论贝那普利联合阿托伐他汀治疗慢性心力衰竭,可改善患者的心功能和炎症状态,明显提高运动耐力。

Objective To analyze the clinical value of benazepril combined with atorvastatin in the treatment of chronic heart failure.Methods A total of 116 patients with chronic heart failure treatred in the First Affiliated Hospital of Nanyang Medical College from April 2019 to April 2022 were selected,and they were divided into observation group and control group according to random number table method,with 58 cases in each group.The control group was treated with benazepril,and the observation group was treated with benazepril combined with atorvastatin.The therapeutic effect,echocardiogram indexes,including left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD),electrocardiogram level assessed by QRS complex(QRS),QT dispersion(QTD)and corrected QT dispersion(QTcd),heart rate variability assessed by total standard deviation of sinus rhythm R-R interval(SDNN),root mean square deviation of adjacent normal R-R interval difference(rMSSD)and mean standard deviation of continuous 5-min normal R-R interval(SDANN),6-min walking test distance,inflammatory factors,including high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α),of the two groups were compared.Results The total effective rate of the observation group(94.83%,55/58)was higher than that of the control group(79.31%,46/58),P<0.05.After treatment,LVEF in the observation group was higher than that in the control group,while LVEDD and LVESD were lower than those in the control group(P<0.05).After treatment,QRs,QTd and QTcd in the observation group were lower than those in the control group(P<0.05),while the SDNN,rMSSD and SDANN in the observation group were higher than those in the control group(P<0.05).After treatment,the 6-min walking test distance of the observation group was longer than that of the control group(P<0.05).After treatment,hs-CRP,IL-6 and TNF-αin the observation group were lower than those in the control group(P<0.05).Conclusions Benazepril combined with atorvastatin in the treatment of chronic heart failure can improve cardiac function and inflammation,and can significantly improve exercise endurance.