摘要
To the Editor:Diabetic kidney disease(DKD)has become the leading cause of end-stage kidney disease(ESKD).According to the Kidney Disease Improving Global Outcomes(KDIGO)guidelines,rapid kidney function decline in DKD is defined as an estimated glomerular filtration rate(eGFR)slope≤−5 mL∙min^(−1)∙1.73 m^(−2)·year^(−1).The prognoses of patients who experience rapid eGFR decline are usually poor.In a multicenter retrospective study,230 of 377(61%)biopsy-proven DKD patients were rapid decliners.[1]It was reported that 32%and 42%of 195 type 2 diabetes(T2D)Pima Indians with normoalbuminuria and microalbuminuria,respectively,had a rapid eGFR decline,indicating that proteinuria alone has difficulty in fully predicting rapid kidney function decline in DKD patients with T2D.[2]Therefore,it is of interest to identify more useful clinicopathological predictors of a rapid kidney function decline in T2D patients.
基金
National Natural Science Fund(Nos.82070748,82090020,and 82090021)
National Key Research and Development Program(Nos.2022YFC2502500 and 2022YFC2502502)
China International Medical Foundation Renal Anemia Fund,and grants from National High-Level Hospital Clinical Research Funding(Nos.2022SF01 and 2022XW01)
