杂化细胞膜仿生纳米药物递送体系用于肿瘤治疗的研究进展

Research progress in the application of hybrid cell membrane biomimetic nano-drug delivery system in cancer treatment

利用细胞膜包覆纳米颗粒的仿生策略不仅能保留纳米颗粒的物理化学性质,而且表现源细胞膜的生物学特性,可进一步增强纳米药物在肿瘤治疗中的作用。杂化细胞膜是将2种或2种以上不同类型的细胞膜融合在一起。与单型细胞膜相比,杂化细胞膜使纳米颗粒衍生出多种源细胞的生物功能,为多功能仿生纳米药物递送体系的广泛研究提供了基础,有望拓宽仿生纳米技术在药物递送体系的应用。综述了近年来用于构建纳米药物递送体系的杂化细胞膜类型,制备和表征方法以及用于肿瘤治疗的研究进展。

The biomimetic strategy of using the cell membrane-coated nanoparticles can retain the physical and chemical properties of the nanoparticles and show the biological characteristics of the source cell membrane,which can further enhance the role of the nanodrug in tumor treatment.A hybrid cell membrane is the fusion of two or more different types of cell membranes.A hybrid cell membrane can endow nanoparticles with multiple biofunctions derived from the source cells compared with a single cell membrane.Hybrid cell membranes provide a foundation to stimulate extensive research into multifunctional biomimetic nano-drug delivery system(NDDS),which is expected to broaden the application of biomimetic nanotechnology in drug delivery systems.In this review paper,the types of hybrid cell membrane used to construct nano-drug delivery systems,the preparation and characterization methods,and cancer treatment research progress in recent years were reviewed.