摘要
两性霉素B(AmB)是目前临床上抗真菌谱最广,活性最强的抗真菌药物,尽管有多种脂质制剂上市,极大地降低了两性霉素B脱氧胆酸盐(AmBd)的不良反应,但价格昂贵。因此,在我国AmBd在未来很长的一段时间内仍有重要的临床地位。为了提高AmBd临床疗效,降低毒副反应,编写组邀请国内该领域知名专家就AmBd的抗菌特性、药动学特点、给药方案、临床应用、不良反应防治等方面达成了共识,规范AmBd的临床应用。
Amphotericin B(AmB)is an antifungal drug with the broadest spectrum and the most robust antifungal activity in clinical practice.Although there are many kinds of lipid formulations which significantly reduce the toxicity and side effects of amphotericin B deoxycholate(AmBd),AmBd will still play an important clinical role in China for a long time since lipid formulations are substantially more expensive.To standardize the clinical application of AmBd,well-known experts in this field were invited to reach a consensus on the antifungal properties,pharmacokinetic characteristics,dosage regimen,clinical application,prevention and treatment of adverse reactions of AmBd.
作者
两性霉素B脱氧胆酸盐临床合理应用专家共识编写组
中国医药教育协会感染疾病专业委员会
中华医学会细菌感染与耐药防控专业委员会
俞云松
刘又宁
王明贵
冯靖
黄英姿
黄志伟
李昕
王俊
吴波
许利军
杨青
张俊丽
周华
周志慧
朱剑萍
Expert Panel for Clinical Rational Application of Amphotericin B Deoxycholate;Infectious Diseases Society of China;Chinese Society of Bacterial Infection and Resistance;Yu Yunsong;Liu Youning;Wang Minggui(不详;Department of Infectious Diseases,Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University,Hangzhou 310016,China;Department of Respiratory and Critical Care Medicine,Chinese People′s Liberation Army General Hospital,Beijing 100853,China;Institute of Antibiotics,Huashan Hospital,Fudan University,Shanghai 200040,China)
出处
《中华医学杂志》
CAS
CSCD
北大核心
2023年第16期1173-1183,共11页
National Medical Journal of China
基金
浙江医药卫生科技计划(2018ZD030,2020KY604)
