迷走神经刺激术治疗儿童药物难治性癫痫的应用进展

Recent advances in vagus nerve stimulation for pediatric drug refractory epilepsy

迷走神经刺激术(vagus nerve stimulation,VNS)是一种安全有效的神经调控治疗手段,在药物难治性癫痫(drug refractory epilepsy,DRE)治疗中的应用较多。VNS不仅可以降低DRE患儿的癫痫发作频率,还有利于患儿的神经发育和社会认知功能改善。近年来,VNS用于治疗儿童DRE的研究越来越多,但儿童VNS术后参数的调控尚无统一标准,VNS治疗癫痫的具体作用机制尚不明确。本文综述VNS治疗儿童DRE的临床疗效、对社会认知和生活质量的改善以及术后参数调控。

As one of safe and effective neuromodulatory therapies in clinical practices,vagus nerve stimulation(VNS)has been widely applied for drug refractory epilepsy(DRE).VNS can not only lower the frequency of seizure in DRE children,but also enhance their neurodevelopmental and social cognitive functions.In recent years,more and more researches have been devoted for VNS treating DRE children.However,there is no uniform standard for parametric regulation after VNS in children and the specific therapeutic mechanism of VNS for epilepsy has remained elusive.This review also elaborated upon improving quality-of-life and social cognitive functions and parametric regulation of VNS for pediatric drug refractory epilepsy.