摘要
EB病毒(Epstein-Barr virus,EBV)感染在儿童肝移植术后较为常见,而EBV相关的移植后淋巴组织增生性疾病(posttransplant lymphoproliferative disease,PTLD)是儿童肝移植术后的严重并发症,可导致受者死亡。近年来儿童肝移植术后EBV感染、病毒载量监测、EBV相关PTLD生物标志物、EBV疫苗及使用利妥昔单抗等药物治疗等方面的研究均有不同程度进展,患者预后较前也明显改善。本文就儿童肝移植术后EBV相关PTLD的诊治进展进行综述。
EBV infection is common after pediatric liver transplantation.And EBV related posttransplant lymphoproliferative disease(PTLD)is a potentially lethal complication.Recently great strides have been made in the managements of EBV infection,PTLD,viral load monitoring,detecting new biomarkers and EBV vaccination,etc.This review focused upon the latest advances in the diagnosis and treatment of EBV related PTLD after pediatric liver transplantation.
作者
赵升桥
孙超
Zhao Shengqiao;Sun Chao(Clinical College of the first center of Tianjin Medical University,Tianjin 300190,China;Tianjin Key Laboratory of organ transplantation,Department of child organ transplantation,Tianjin First Central Hospital,Tianjin 300192,China)
出处
《临床小儿外科杂志》
CAS
CSCD
2023年第1期79-83,共5页
Journal of Clinical Pediatric Surgery
基金
天津市医学重点学科(专科)建设项目(TJWJ2022XK017)
关键词
肝移植
疱疹病毒4型
人
淋巴组织增殖性疾病
Liver Transplantation
Herpesvirus 4,Human
Lymphoproliferative Disorders
