肿瘤微环境pH值差异与膀胱癌的相关性

Correlations between different pH values in tumor microenvironment and bladder cancer

与正常组织相比,肿瘤细胞的胞外间质pH值偏酸性。肿瘤细胞表面跨细胞膜的反向pH梯度与其不受控制的进展、血管生成和转移密切相关。尿pH的变化通过调节膀胱癌细胞的微环境,对膀胱癌的发生、进展和治疗产生影响。相关研究显示,尿pH值是预测膀胱癌患者联合碱化剂治疗最终临床疗效的重要因素,有助于反映体内酸碱平衡和免疫防御系统。持续监测尿pH值可以为膀胱癌患者的预后提供指导和决策。

Compared with normal tissue,interstitial extracellular pH of tumor cells is acidic.The reverse transmembrane pH gradient around tumor cells is closely related to its uncontrolled progression,angiogenesis and metastasis.Changes in urinary pH have an impact on the occurrence,progression and treatment of bladder cancer by regulating the microenvironment of bladder cancer cells.Relevant studies have shown that urinary pH value is an important factor in predicting the final clinical efficacy of bladder cancer patients combined with alkalization agents,which helps to reflect the acid-base balance and immune defense system in the body.Continuous monitoring of urinary pH can provide guidance and decision-making for the prognosis of bladder cancer patients.