PI3K通路在肿瘤免疫微环境中的作用机制

Mechanism of PI3K pathway in tumor immune microenvironment

免疫抑制性肿瘤微环境是影响免疫检查点抑制剂疗效的重要因素之一。磷脂酰肌醇3-激酶(PI3K)相关信号通路是参与肿瘤发生发展的重要通路,该通路的异常激活与肿瘤免疫抑制性微环境的形成有着错综复杂的联系。深入讨论PI3K相关通路在肿瘤微环境中的作用机制,可以为提高免疫治疗疗效提供一定的方向和思路,发掘免疫治疗的潜力。

Immunosuppressive tumor microenvironment is one of the important factors affecting the efficacy of immune checkpoint inhibitors.The phosphatidylinositol 3-kinase(PI3K)-related signaling pathway is an important pathway involved in the occurrence and development of tumors,and the abnormal activation of this pathway is inextricably linked with the immunosuppressive tumor microenvironment.In-depth discussion of the mechanism of PI3K-related pathways in the tumor microenvironment can provide certain directions and ideas for improving the efficacy of immunotherapy,and explore the potential of immunotherapy.