男童外生殖器萎缩性硬化性苔藓的治疗进展

Recent advances in treatment of genitourinary lichen sclerosus in boys

萎缩性硬化性苔藓(lichen sclerosus,LS)是一种容易被忽视的皮肤苔藓样变,该病往往于儿童期发病且容易忽视,在青春期和中年期之间存在很长的潜伏期,中年期后存在再次发病的可能。LS可以导致阴茎头包皮僵硬狭窄、阴茎头上皮萎缩、包皮内板上皮剥脱,严重情况下可以导致包皮与阴茎头完全融合粘连或尿道口狭窄,增加阴茎癌患病风险。男童LS的治疗困难,目前治疗的主要目的在于消除高风险因素、延缓病情进展和预防性早期干预,治疗方式存在很大的主观性。本文就男童外生殖器LS的治疗现状进行综述,旨在为今后男童LS的临床干预提供参考。

Lichen sclerosus(LS)is an easily overlooked dermal lichenification in childhood with a long incubation period during adolescence and middle age and a possibility of recurrence after middle age.LS leads to stiffness and stenosis of glans penis prepuce,atrophy of glans penile epithelium and epithelial exfoliation of inner prepuce plate.In severe cases,complete fusion and adhesion of prepuce and glans penis or stenosis of urethral meatus may elevate the risk of penile cancer.LS is difficult to treat in boys and the main objective of current treatment is to eliminate high-risk factors,delay disease development and implement early interventions.Its treatment modalities are quite subjective.This reviews summarized current status of managing LS of external genitalia in boys to provide references for proper clinical interventions.