神经表皮生长因子样蛋白1在膜性肾病中的研究进展

Progress of research on NELL-1 in membranous nephropathy

膜性肾病(MN)是一种常见的肾小球疾病,其发病机制为抗体与足细胞上的抗原结合后,免疫复合物在肾小球基底膜外沉积,从而引发补体激活、足细胞损伤、肾小球基底膜结构改变。近年来发现,神经表皮生长因子样蛋白1(NELL-1)是继MN主要靶抗原M型磷脂酶A2受体之后的一个MN新型靶抗原,与节段性MN、肿瘤关系密切。本文就MN新型靶抗原NELL-1的结构、表达等最新研究进展进行了综述。

Membrane nephropathy(MN)is a common glomerular disease.Its pathogenesis is that as the antibody combines its podocyte antigen,immune complexes deposit in the glomerular basement membrane,which in turn leads to complement activation,podocyte damage,and structural changes in the glomerular basement membrane.In recent years,it has been found that neural epidermal growth factor-like 1 protein(NELL-1)is a new target antigen of MN after the finding of the main target antigen of MN,M-type phospholipase A2 receptor(PLA2R).NELL-1 is closely related to segmental MN and tumors.This review focused on the new progress of research on NELL-1 in its structure,expression,etc.