间充质干细胞治疗缺血性脑卒中机制的研究进展

Research progress in the mechanism of mesenchymal stem cells in the treatment of ischemic stroke

缺血性脑卒中(IS)是由于脑血管闭塞导致脑血液循环中断而引起的神经功能障碍,给大量患者带来了不同程度的残疾负担。目前,IS发病率、患病率和死亡率整体呈上升趋势,成为亟待解决的公共卫生问题。然而,IS的治疗手段有限,预后仍不满意。值得注意的是,间充质干细胞(MSC)因能够促进受损中枢神经系统的功能恢复,已经成为基础研究和临床研究的热点。本文汇总了MSC的来源和给药途径,重点回顾了MSC治疗IS机制的研究进展以及临床研究现状,旨在为后续MSC在IS中的临床治疗策略探索提供参考。

Ischemic stroke(IS)is a neurological disorder caused by cerebral vascular occlusion,which leads to the interruption of cerebral blood circulation.It brings varying degrees of disability burden to a large number of patients.At present,the incidence,prevalence,and mortality of IS are on the rise as a whole,which has become a public health problem to be solved urgently.However,the treatment of IS is limited,and the prognosis is unsatisfactory.It is worth noting that mesenchymal stem cells(MSCs)have become the focus of basic and clinical research because they are speculated to promote the functional recovery of the damaged central nervous system.This review summarizes the sources and administration routes of MSCs,and focuses on the research progress in the mechanism and the clinical research status of MSCs in the treatment of IS,in order to provide a reference for the further exploration of clinical treatment strategies of MSCs in IS.