安坤种子丸联合芬吗通对卵巢储备功能下降患者黄体生成激素与硫酸脱氢表雄酮的影响

Effect of Ankun Zhongzi pills combined with Femoston on luteinizing hormone and dehydroepiandrosterone sulfate in patients with decreased ovarian reserve function

目的研究安坤种子丸联合芬吗通对卵巢储备功能下降患者黄体生成激素与硫酸脱氢表雄酮(DHEA-S)的影响。方法纳入研究100例于2019年5月~2021年5月在琼海市中医院妇科进行治疗卵巢储备功能下降患者,通过掷骰子法分为对照组和研究组,每组患者各50例,先给予2组患者口服维生素E以及多吃豆类食品的常规治疗。对照组患者在进行常规治疗后采用口服治疗芬吗通,研究组在进行常规治疗后采用口服治疗安坤种子丸+芬吗通,观察2组治疗后黄体生成激素(LH)、DHEA-S水平、促卵泡生成素(FSH)、雌二醇(E2)水平以及抗缪勒管激素(AMH)、电化学发光发检测性激素结合球蛋白(SHBG)的变化,治疗后对2组不良反应及有效率进行统计。结果2组患者治疗后DHEA-S、LH、FSH水平明显低于治疗前,E2水平高于治疗前(P<0.05);研究组治疗后DHEA-S、LH、FSH水平低于对照组,E2水平高于对照组(P<0.05)。治疗后2组患者SHBG、AMH均高于2组治疗前;研究组治疗后SHBG、AMH均高于对照组且治疗后总有效率明显高于对照组(P<0.05)。结论安坤种子丸+芬吗通能有效改善卵巢储备功能下降患者体内LH、DHEA-S以及雌激素水平,卵巢储备功能恢复较好。

Objective To investigate the effects of Ankun Zhongzi pills combined with Femoston on luteinizing hormone and dehydroepiandrosterone sulfate(DHEA-S)in patients with decreased ovarian reserve.Methods A total of 100 patients with decreased ovarian reserve function were enrolled at Qionghai City Hospital of Traditional Chinese Medicine of Gynecology from May 2019 to May 2021.They were randomly divided into either a control group or a study group by rolling dice,with 50 patients in each group.The two groups were first given oral vitamin E and conventional treatment(eating more soy food).Patients in the control group received oral treatment of Femoston after routine treatment,and patients in the study group received oral treatment of Ankun Zhongzi pills+Femoston after routine treatment.After treatment,the levels of luteinizing hormone(LH),DHEA-S,follicle-stimulating hormone(FSH),estradiol(E2),and anti-Mullerian hormone(AMH)were determined,and electrochemiluminescence detection of sex hormone binding globulin(SHBG)was performed.The rate of adverse reactions and the effective rate were statistically analyzed in the two groups.Results After treatment,the levels of DHEA-S,LH,and FSH in both groups were significantly lower than those before treatment,while the level of E2 was significantly higher than that before treatment(P<0.05).The levels of DHEA-S,LH,and FSH in the study group were significantly lower than those in the control group,while the level of E2 was significantly higher than that in the control group(P<0.05).After treatment,SHBG and AMH in both groups were significantly higher than those before treatment(P<0.05);SHBG and AMH in the study group were significantly higher than those in the control group(P<0.05).The total effective rate was significantly higher in the study group than in the control group(P<0.05).Conclusion Ankun Zhongzhi pills combined with Femoston can effectively improve the levels of LH,DHEA-S,and estrogen in patients with decreased ovarian reserve,and the ovarian reserve can recover better.