lncRNA在创伤性脑损伤中的研究进展

Research progress of lncRNA in traumatic brain injury

创伤性脑损伤(TBI)在全球具有较高的发病率、致残率及死亡率,因其病理机制的复杂性、多层次性及异质性等,常规临床治疗效果欠佳,给个人、家庭和社会带来巨大的负担。长链非编码RNA(lncRNA)是一类长度>200 nt的RNA,与TBI中各种信号转导、炎症通路、免疫反应、离子通道及细胞周期的发生发展息息相关。本文主要综述lncRNA通过炎症通路及免疫相关炎症在TBI中所起的作用,以期通过调控lncRNA的表达水平为TBI患者的治疗带来新的契机。

Traumatic brain injury(TBI)has a very high morbidity,disability and mortality rate in global.Due to the complexity,multi-level,heterogeneity and other factors of its pathological mechanism,poor effect of conventional clinical treatment brings a huge burden to individuals,families and society.Long noncoding RNA(lncRNA)is a type of RNA with a length of more than 200 nt,which is closely related to the occurrence and development of various signal transduction,inflammation pathways,immune response,ion channels and cell cycle in TBI.This article mainly reviews the role of lncRNA in TBI through inflammatory pathway and immune-related inflammation in TBI,in order to bring new opportunities for the treatment of TBI patients by regulating the expression level of lncRNA.