细菌外膜囊泡在ARDS中的功能及机制研究进展

Advances on function and mechanism of bacterial outer membrane vesicles in acute respiratory distress syndrome

急性呼吸窘迫综合征(ARDS)是以失控炎症反应为发病机制及难治性低氧血症为主要临床特征的致命性疾病,感染是其最常见的诱因。外膜囊泡(OMVs)是革兰氏阴性菌分泌的纳米球形颗粒,载有大量细菌成分。近年来研究表明OMVs在细菌定植、毒力因子递送和调控宿主免疫反应中起着重要的作用。本文就OMVs在ARDS免疫反应中的功能及机制进行综述。

Acute respiratory distress syndrome(ARDS),a fatal disease characterized by uncontrolled immune response and refractory hypoxemia,is most commonly induced by infection.Outer membrane vesicles(OMVs)are nanoparticles produced by gram-negative bacteria via the extrusion of the outer membrane and can deliver a range of bacterial molecules to host cells.Recently it was found that OMVs play vital roles in bacterial colonization,delivery of virulence factors,and disease pathogenesis.This article reviews the formation and biological functions of OMVs,and the inflammatory and pathological mechanisms of OMVs in ARDS.