GLP-1RA类药物在减重治疗中的临床应用效果

Clinical effectiveness of GLP-1RA class drugs in weight reduction treatment

肥胖及其代谢相关问题目前已经成为临床治疗上的热点问题。胰高糖素样肽-1受体激动剂(glucagon-like peptide-1 receptor agonists,GLP-1RA)是近年来的新型降糖药,可通过激活GLP-1受体,以葡萄糖浓度依赖的方式增强胰岛素分泌,抑制胰高糖素分泌,同时能够延缓胃排空,通过中枢性的食欲抑制减少进食量,从而达到降低血糖、减轻体重、改善代谢。近年来已有报道GLP-1RA运用于临床减重及降糖,GLP-1RA是否可以在临床中代替减重手术,目前还处于未知。本文探讨GLP-1RA在减重中的临床应用效果。

Obesity and its metabolic problems have become a hot topic in clinical treatment.Glucagon-like peptide-1 receptor agonists(GLP-1RA)are new hypoglycemic drugs in recent years,which can enhance insulin secretion and inhibit Glucagon secretion in a glucose concentration-dependent manner by activating GLP-1 receptor.At the same time,it can delay gastric empting,reduce food intake through central appetite suppression,so as to reduce blood glucose,reduce body weight and improve metabolism.In recent years,GLP-1RA has been reported to be used in clinical weight loss and hypoglycemia.Whether GLP-1RA can replace bariatric surgery in clinical practice is still unknown.This article will review the clinical application effect of GLP-1RA in weight loss.