MUC16/CA125在良恶性肿瘤诊治中的作用及其研究进展

Progress in understanding of role of MUC16/CA125 in diagnosis and treatment of benign and malignant tumors

MUC16/CA125是一种糖类蛋白肿瘤标志物,可来源于间皮细胞组织、米勒管上皮及两者衍生物所发生的良恶性疾病。MUC16/CA125在良恶性肿瘤中的作用不同,一方面,通过MUC16-siglec-9、MUC16-galectin-1/3、MUC16-Mesothelin、MUC16-选择素和MUC16-JAK2等信号通路参与恶性肿瘤的发生发展、侵袭和转移,另一方面,其在非恶性肿瘤中主要起到了局部缓冲、润滑、抗炎及维持内环境稳态的功能。本文针对于血清CA125升高相关疾病的鉴别进行了讨论,以及MUC16/CA125可能作为新型特异性肿瘤标志物和更多的新型靶向药物进行了阐述。

MUC16/CA125 is a kind of glycoprotein tumor marker that can originate from mesothelial cells,Miller duct epithelium in benign tissue,and their derivatives in malignant diseases.MUC16/CA125 has different roles in benign and malignant tumors.On the one hand,it participates in the occurrence and development of malignant tumors through signaling pathways such as MUC16-siglec-9,MUC16-galectin-1/3,MUC16-mesothelin,MUC16-selectin,and MUC16-JAK2.On the other hand,it mainly has the functions of local buffering,lubrication,anti-inflammation,and maintaining homeostasis in nonmalignant tumors.In this paper,we discuss the identification of diseases related to elevated serum CA125 and its role in the diagnosis and treatment of benign and malignant tumors.Further research is needed to explore MUC16/CA125 as a new specific tumor marker and target for new drugs.