成纤维细胞生长因子21与血管钙化关系研究进展

Research progress on the relationship between fibroblast growth factor 21 and vascular calcification

成纤维细胞生长因子21(FGF21)是成纤维细胞生长因子家族的一员,具有降脂、抗炎、抗氧化等生物学作用。近年来研究发现,FGF21能够有效抑制血管钙化,降低心血管事件的发生,被视为心血管系统新的保护因素,有望成为临床上防治血管钙化的新靶点。本文就FGF21与血管钙化关系的最新研究进展做一综述。

Fibroblast growth factor 21(FGF21)is a member of the fibroblast growth factor family,which has biological effects such as lipid-lowering,anti-inflammation and anti-oxidation.In recent years,studies have found that FGF21 can effectively inhibit vascular calcification and reduce the occurrence of cardiovascular events.So,it has been regarded as a new protective factor for the cardiovascular system,and is expected to become a new clinical target for the prevention and treatment of vascular calcification.This article reviewed the latest research progress on the relationship between FGF21 and vascular calcification.