过氧化物酶体增殖物激活受体在骨关节炎中的研究进展

Research progress of peroxisome proliferators-activated receptors in osteoarthritis

骨关节炎(OA)是一种关节退行性病变。目前OA的特殊发病机制尚不清楚。有研究发现过氧化物酶体增殖物激活受体(PPAR)可通过纠正脂代谢紊乱、抗炎、抗软骨细胞凋亡等机制改善OA的病情发展。这篇综述旨在讨论PPAR的生物学功能,以及它们在OA疾病发展进程中的调节作用和治疗作用。

Osteoarthritis(OA)is a degenerative disease of joint.At present,the specific pathogenesis of OA is not clear.Studies have found that peroxisome proliferator activated receptor(PPAR)can improve the development of OA by correcting the disorder of lipid metabolism,anti-inflammatory,anti chondrocyte apoptosis and other mechanisms.This review aimed to discuss the biological functions of PPAR and their regulatory and therapeutic roles in the development of OA.