机械敏感离子通道在脊柱退行性疾病的研究进展

Research progress of mechanical sensitive ion channel in spinal degenerative diseases

椎间盘退变和脊柱小关节炎是常见的退行性疾病,它是慢性腰痛并间歇性急性发作的重要病因,涉及力学、遗传和生物学等多因素诱发的退行性改变,表现为椎间盘和小关节结构的破坏和功能的减退。压电型机械敏感离子通道蛋白(Piezo1)被认为是力学环境下椎间盘退变和关节炎的关键因子。Piezo1在退变椎间盘组织和关节组织中异常激活,并深度参与椎间盘退变和关节炎的发病机制。因此,本文将从椎间盘和脊柱小关节的角度,进行Piezo1对椎间盘退变和关节炎的文献综述,以期了解其对椎间盘退变和小关节紊乱方面的机制,为未来研究提供方向,为该类疾病的治疗提供靶点。

Intervertebral disc degeneration and spinal facet joint arthritis are comman spinal degenerative diseases.It is important causes of chronic low back pain and intermittent acute attacks.It is a degenerative change induced by multiple factors including mechanics,genetics and biology,which is manifested in the destruction of the structure and function of intervertebral discs and facet joints.Mechanical sensitive ion channel protein Piezo1 is considered as the key factor of intervertebral disc degeneration and facet joint osteoarthritis under mechanical environment.Piezo1 is abnormally activated in degenerative intervertebral disc tissue and joint tissue,and deeply participates in the pathogenesis of intervertebral disc degeneration and osteoarthritis.Therefore,this article made a review from the perspective of Piezo1 on intervertebral disc degeneration and osteoarthritis,in order to understand its mechanism on intervertebral disc degeneration and facet joint disorder,provide direction for future research,and provide a therapeutic targets for those diseases.