肥胖及减重手术与下肢骨关节炎的研究进展

Research progress on lower limb osteoarthritis affected by obesity and bariatric surgery

肥胖可通过生物力学和全身炎症促进下肢骨关节炎的发生发展,进而造成关节结构损伤、功能受限。减重手术作为治疗肥胖最有效的方法之一,可以有效缓解关节症状、减缓甚至逆转骨关节炎的进展。本文从肥胖与下肢骨关节炎发生的相关性及潜在机制,综述肥胖在下肢骨关节炎发生中的作用。此外,本文针对减重手术对肥胖患者下肢骨关节炎的疗效及机制进行了总结,以期为肥胖患者骨关节炎的治疗提供新的思路和方向。

Obesity promotes the pathogenesis of osteoarthritis of the lower extremities through biomechanical and systemic inflammatory changes,which result in structural damage to the joint and limited function.Bariatric surgery is one of the most effective methods to treat obesity,which can effectively relieve joint symptoms and slow or even reverse the progression of osteoarthritis.This article reviews the role of obesity in developing lower limb osteoarthritis from the correlation and potential mechanism between obesity and osteoarthritis.In addition,this article summarizes the effect and mechanism of bariatric surgery on lower limb osteoarthritis in obese patients to provide new ideas and directions for the treatment of obese patients with osteoarthritis.