髌股关节炎病因相关促炎因子研究进展

Research progress on etiology of patellofemoral arthritis based on proinflammatory cytokines

随着社会的老龄化及人们生活方式的改变,髌股关节炎发病率目前逐渐上升,大部分膝关节炎认为是髌骨与股骨之间的病变。本文回顾以往对于髌股关节炎的发病机制的相关文献,着重从细胞因子水平阐述相关病理变化,论述前列腺素E2(PGE2)、白细胞介素(IL)-1β、IL-6、肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶(MMPs)等相关促炎因子对于髌股关节炎的病因及发病机制之间的相关性,为髌股关节炎的诊治及更进一步的研究提供理论方向。

With an aging society and changes in lifestyles,the incidence of patellofemoral arthritis is currently increasing.Most of the knee arthritis is considered as a lesion between the patella and the femur.This article reviewed the previous literatures on the pathogenesis of patellofemoral arthritis,focused on the related pathological changes from the level of cytokines and discussed prostaglandin E2(PGE2),interleukin(IL)-1β,IL-6,tumor necrosis factor(TNF)-α,matrix metalloproteinases(MMPs)and other related inflammatory factors that associate with the etiology and pathogenesis of patellofemoral arthritis.It may provide theoretical directions in diagnosis and treatment of patellofemoral arthritis as well as for further research.