目标体温管理对心脏骤停患者脑保护作用的研究进展

Progress in the study of the cerebral protective effect of target temperature management in cardiac arrest patients

目标体温管理(TTM)是一种根据设定方案进行体温管理的治疗方法,在心脏骤停复苏成功的患者中广泛应用。近年来,关于TTM对心脏骤停患者脑保护作用的临床实践研究取得了重大进展,但也存在很大的争议。不同研究的纳入人群、采取的低温诱导技术及治疗的目标温度达标时间等条件不同,而且临床实验并不能完全模拟基础实验完整的、标准的条件,在实际应用TTM时会受到多种限制。本文围绕TTM对心脏骤停患者脑保护作用的研究进展作一综述。

Targeted temperature management (TTM) is a therapeutic approach to temperature management according to a set protocol that is widely used in patients resuscitated successfully from cardiac arrest. In recent years, there have been significant advances in clinical practice studies on the cerebral protective effects of TTM in cardiac arrest patients, while it is also controversial from many sides. Different studies have different conditions such as the inclusion population, the hypothermia induction technique adopted and the time of reaching the target temperature for treatment. Moreover, the clinical trials do not fully simulate the complete and standard conditions of the basic trials, which will be subject to various restrictions in the actual application of TTM. This article reviews the research progress of TTM on brain protection in patients with cardiac arrest.