中国老年人肌少症患病率和影响因素的Meta分析

Prevalence and risk factors of sarcopenia in the elderly in China:A meta-analysis

目的探讨中国老年人肌少症的患病率及其影响因素。方法检索PubMed、Embase、Cochrane图书馆、Web of Science、Medline、中国知网、万方医学网等全文数据库,收集有关老年人肌少症患病率及影响因素的中、英文文献。对符合纳入标准的文献进行数据提取和质量评价,采用Stata 12软件进行Meta分析。结果本研究最终纳入文献22篇。纳入文献Meta分析显示,中国老年人肌少症患病率为14.6%(95%CI:0.13~0.18)。年龄(OR=1.13,95%CI:1.12-1.13,P<0.01)、性别(OR=1.09,95%CI:1.01~1.19,P<0.01)、糖尿病病史(OR=1.03,95%CI:0.76~1.40,P<0.05)、高体质量指数(OR=0.66,95%CI:0.43~1.00,P<0.05)、<6 h睡眠时长(OR=2.68,95%CI:1.56~4.58,P<0.01)是老年人肌少症的相关影响因素。结论中国老年人肌少症患病率较高,高龄、女性、糖尿病、低体质量指数、睡眠时间少是老年人发生肌少症的危险因素。

Objective To investigate the prevalence and influencing factors for sarcopenia in elderly Chinese.Methods The full-text databases of PubMed,Embase,Cochrane Library,Web of Science,Medline,CNKI and Wanfang data etc.were searched to collect Chinese and English literatures about the prevalence and risk factors of sarcopenia in the elderly Chinese.Data extraction and quality evaluation were conducted for the literature that met the inclusion criteria.Stata 12 software was used for meta analysis.Results Twenty-two articles were included in the study.The prevalence of sarcopenia in the elderly in China was 14.6%(95%CI:0.13~0.18).The risk factors for sarcopenia in elderly Chinese included age(OR=1.18,95%CI:1.12~1.13,P<0.01),gender(OR=1.09,95%CI:1.01~1.19,P<0.01),diabetes(OR=1.03,95%CI:0.76~1.40,P<0.05),high level of the body mass index(OR=0.66,95%CI:0.43~1.00,P<0.01),<6 h sleep time(OR=2.68,95%CI:1.56~4.58,P<0.01).Conclusion The prevalence of sarcopenia in the elderly is high in China.Older age,female,diabetes,low body mass index and shorter sleep time are risk factors for sarcopenia in the elderly.