雄激素受体在乳腺癌应用中的探索之路

Androgen receptor: discoveries in breast cancer clinical practice

乳腺癌是世界范围内发病率最高的恶性肿瘤,目前乳腺癌治疗已进入以分子标志物为指导的分类治疗时代。雄激素受体(AR)是乳腺癌中常见的分子标志物,对乳腺癌细胞活动起调控作用。在临床中,AR表达与乳腺癌患者预后存在一定相关性。AR靶向治疗和相关联合治疗正处于研究中。本文通过查阅近年来相关文献,分别从AR的作用机制、表达与临床价值、相关治疗等方面对AR在乳腺癌应用中的探索进行综述。

Breast cancer is the malignant tumor with the highest incidence in the world.At present,breast cancer treatment has entered the era of classified treatment guided by molecular markers.Androgen receptor(AR)is a commonly expressed molecular marker in breast cancer,which regulates breast cancer cell activities.In clinical practice,AR expression has an appreciated correlation with the prognosis of breast cancer patients,and AR-targeted therapy and related combination therapies are under investigation.This article summarizes the application of AR in breast cancer from the aspects of mechanism,expression and clinical value,and related therapies,by reviewing the relevant literature in recent years.