摘要
学术背景:长期以来,研究者一直认为骨骼肌是单纯的运动器官。但近年研究发现,运动中骨骼肌会产生大量的白细胞介素6,而白细胞介素6作为运动应激中产生的细胞因子,对机体的代谢、炎症和疾病都产生一定的影响。目的:文章总结了国外近年来的研究,试从肌源性白细胞介素6生物学作用方面进行初步探讨。检索策略:应用计算机检索Medline1991-01/2005-12期间的相关文章,检索词"IL-6,physicalexercise",限定文章语言种类为英文。文献评价:文献的来源主要是关于肌源性白细胞介素6对机体的代谢、健康的影响。所选的31篇文章,以临床实验研究为主,另有少部分基础实验研究。资料综合:①过去研究一直认为骨骼肌只是运动器官,但近年发现运动中骨骼肌会产生大量的白细胞介素6。②肌源性白细胞介素6作为一种运动应激中产生的细胞因子,可能通过对机体糖、脂肪的代谢以及抗炎功能的影响来调整机能状态,从而对糖尿病等疾病产生良好的调节作用。③研究还发现规律运动可以降低白细胞介素6的水平,而一些代谢疾病如二型糖尿病白细胞介素6的水平明显升高,是否可以通过补充白细胞介素6来治疗代谢疾病,是一个值得研究的领域,也是以后纠正代谢紊乱疾病的一个方向。结论:大量研究表明,规律运动对健康有良好的促进作用。肌源性白细胞介素6作为一种运动中产生的细胞因子,可能是通过影响脂肪、葡萄糖的代谢以及对炎症的抑制作用来调节机体功能。研究肌源性白细胞介素6的作用机制,有助于找到某些代谢疾病的发病机制以及评价运动对机体的作用。
BACKGROUND: For a long time, the researchers have thought that skeletal muscles are simply sport organs. However, it is discovered that the massive interleukin-6 is generated from the skeletal muscles during exercise. As the cytokine produced in exercise, interleukin-6 displays some effects on body metabolism, inflammation and diseases. OBJECTIVE: To primarily explore the biology of muscle-derived interleukin-6 by summarizing the related oversea researches. RETRIEVE STRATEGY: The relevant English articles dated between January 1991 and December 2005 were searched in Medline with the
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2007年第51期10327-10330,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
关键词
白细胞介素6
代谢
炎症
胰岛素抗药性
组织构建
of 'interleukin-6, physical exercise'. LITERATURE EVALUATION: The articles about the study on the influence of muscle-derived interleukin-6 on body metabolism and health were collected. Finally 31 articles were selected, mainly the clinical experiments besides few basic studies. DATA SYNTHESIS: ①The previous researchers thought that the skeletal muscles were simply sport organs. However, it is discovered that interleukin-6 is generated from skeletal muscles during exercise. ②As a cytokine producing during exercise, interleukin-6 could regulate body condition by influencing glycogen and fat metabolism and inflammation, and accordingly display good effect on the diseases such as diabetes. ③It is also discovered that regular exercise can reduce the level of interleukin-6, but in the diseases such as diabetes the level of interleukin-6 increased markedly. So we can suppose that intake of interleukin-6 maybe cure the diseases such as diabetes, and it is a possible field to treat metabolic disorder diseases. CONCLUSION: It has been demonstrated that regular exercise is beneficial to health. As a cytokine producing during exercise, interleukin-6 mediates the body function through regulating glycogen metabolism and fat metabolism and inhibiting inflammation. The study on the mechanism of interleukin-6 may help to find out the mechanism of some metabolic diseases and evaluate the effect of exercise.
