喉鳞状细胞癌组织中COX-2、Ki-67、VEGF的表达及意义

Expression of COX-2,Ki-67,VEGF in Laryngeal Squamous Carcinoma and Its Significance

目的探讨环氧化酶-2(COX-2)、核增殖抗原(Ki-67)、血管内皮生长因子(VEGF)在喉癌组织中的表达及意义。方法应用SP法检测36例喉鳞状细胞癌、7例癌旁正常喉组织和9例声带息肉中COX-2、Ki-67、VEGF的表达情况。结果COX-2、Ki-67、VEGF在人喉癌组织中表达阳性率分别为58.3%(21/36)、72.2%(26/36)和77.7%(28/36);在声带息肉中为0(0/9)、22.2%(2/9)和33.3%(3/9);癌旁正常喉组织中为0(0/1)、14.3%(1/7)和42.9%(3/7);COX-2、Ki-67和VEGF在喉癌组织的表达呈正相关(P<0.05)。结论COX-2、Ki-67、VEGF的表达与人喉癌的发生、发展有一定的相关性,3者表达强度之间呈正相关,可作为临床诊断的重要参考指标。

Objective To explore the expression of COX-2,Ki-67,VEGF in carcinoma of larynx and its significance.Methods lmmunohistochemical methods were used to detect the expression of COX-2,Ki-67,VEGF in 39 cases of laryngeal carcinoma,7 cases of normal laryngeal tissues and 9 cases of vocal cords polypus.Results The positive rate of COX-2,Ki-67,VEGF was 58.3%(21/36),72.2%(26/36) and 77.7%(28/36) in laryngeal carcinoma,0(0/9),22.2%(2/9) and 33.3%(3/9)in vocal cords polypus,0(0/1),14.3%(1/7) and 42.9%(3/7) in normal laryngeal tissues respectively,positively expressive correlation of COX-2,Ki-67,VEGF in carcinoma of larynx(P<0.05).Conclusion The occurrence and development of laryngeal carcinoma may be closely related to the expression of COX-2,Ki67 and VEGF.In addition,they have positively expressive correlation.COX-2,ki-67,VEGF may be the prognostic discriminators in laryngeal Carcinoma.