期刊文献+

他汀类药的相关肌病 被引量:5

下载PDF
导出
摘要 提要:他汀类药(statins)是3-羟-3-甲戊二酰辅酶A(3-hydroxy-3-methylglutaryl-coenzyme A,HMG-CoA)的竞争性抑制药,能有效减少胆固醇合成,调节血脂、防治心脑血管疾病。他汀类药安全性较高,其不良反应以肌病占较高比例,严重时甚至能引起致死性横纹肌溶解。本文简述他汀类药引起肌病及其可能的发生机制。
作者 黄蔚 张萍
出处 《岭南心血管病杂志》 2007年第5期373-375,共3页 South China Journal of Cardiovascular Diseases
  • 相关文献

参考文献19

  • 1[1]BRIEL M,NORDMANN A J,BUCHER H C.Statin therapy for prevention and treatment of acute and chronic cardiovascular disease:update on recent trials and metanalyses[J].Curr Opin Lipidol,2005,16 (6):601-605.
  • 2张奇.他汀类药物临床应用注意点[J].临床内科杂志,2006,23(1):12-15. 被引量:8
  • 3[3]VASUDEVAN A R,HASMIN Y S,JONES P H.Safety of statins:effects on muscle and the liver[J].Cleve Clin J Med,2005,72 (11):990-1001.
  • 4[4]LAW M,RUDNICKA A R.Statin safety:a systematic review[J].Am J Cardiol,2006,97 (8A):52-60.
  • 5[5]BOTTORFF M B.Statin safety and drug interactions:Clinical Implications[J].Am J Cardiol,2006,97 (8A):27-31.
  • 6[6]PRUEKSARITANONT T,ZHAO J J,MA B,et al.Mechanistic on metabolic interactions between gemfibrozil and statin[J].J Pharmacol Exp Ther,2002,301 (3):1042-1051.
  • 7[7]HAMILTO N,CRAIG I.Statin-associated myopathy[J].Med J Aust,2001,175(9):486-489.
  • 8[8]GRAHAM D J,STAFFA J A,SHATIN D,et al.Incidence of hospitalized rhabcomyolysis in patients treated with lipid-lowering drugs[J].JAMA,2004,292 (21):2585-2590.
  • 9[9]CZIRAKY M J,WILLEY V J,MCKENNEY J M,et al.Statin safety:an assessment using an administrative claims database[J].Am J Cardiol,2006,97 (8A):61-68.
  • 10[10]STAFFA J A,CHANG J,GREEN L.Cerivastatin and reports of fatal rhabdomyolysis[J]-N Engl J Med,2002,346(7):539-540.

二级参考文献60

  • 1邱洪,中国循环杂志,1998年,13卷,374页
  • 2Jacobso R H,JAMA,1997年,277卷,296页
  • 3邱洪 祁哲 陈纪林 等.普伐他汀导致横纹肌溶解症一例[J].中国循环杂志,1998,13:374-379.
  • 4Downs JR, Clearfield M, Weis S, et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA, 1998, 279:1615-1622.
  • 5Black DM, Bakker-Arkema RG, Nawrocki JW. An overview of the clinical safety profile of atorvastatin (lipitor), a new HMG-CoA reductase inhibitor. Arch Intern Med, 1998, 158:577-584.
  • 6Stein E. Cerivastatin in primary hyperlipidemia: a multicenter analysis of efficacy and safety. Am J Cardiol, 1998, 82:40J-46J.
  • 7Keogh A, Macdonald P, Kaan A, et al. Efficacy and safety of pravastatin vs simvastatin after cardiac transplantation. J Heart Lung Transplant, 2000, 19:529-537.
  • 8Kantola T, Kivisto KT, Neuvonen PJ. Effect of itraconazole on cerivastatin pharmacokinetics. Eur J Clin Pharmacol, 1999, 54:851-855.
  • 9Plotkin E, Bernheim J, Ben-Chetrit S, et al. Influenza vaccine -a possible trigger of rhabdomyolysis induced acute renal failure due to the combined use of cerivastatin and bezafibrate. Nephrol Dial Transplant, 2000 ,15:740-741.
  • 10Duell PB, Connor WE, Illingworth DR. Rhabdomyolysis after taking atorvastatin with gemfibrozil. Am J Cardiol, 1998, 81:368-369.

共引文献89

同被引文献65

引证文献5

二级引证文献22

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部