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胆固醇酯转运蛋白基因多态性与他汀类药的调脂效应

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摘要 提要:胆固醇酯转运蛋白作为参与细胞胆固醇代谢过程的一个关键成员,其基因的某些单核苷酸多态如TaqIB,I405V,-629C/A,-631C/A,-971G/A等能影响他汀类药对心血管疾病患者血清胆固醇水平的调节作用。表明胆固醇酯转运蛋白基因单核苷酸多态性可能影响他汀类药的调脂效果及冠心病的疗效。
作者 张鹏辉 郑克勤
机构地区 广东医学院医学遗传学研究室
出处 《岭南心血管病杂志》 2007年第5期379-380,共2页 South China Journal of Cardiovascular Diseases
基金 广东省自然科学基金项目(项目编号KZ0409)
关键词 胆固醇酯转运蛋白基因 单核苷酸多态性 他汀类药 调脂效应
分类号 R543.5 [医药卫生—心血管疾病] R972+.6 [医药卫生—药品]
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参考文献13

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二级参考文献6

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岭南心血管病杂志
2007年 第5期

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