摘要
系统性红斑狼疮(SLE)为自身免疫性疾病所引起的一种慢性炎症状态,现代医学以皮质激素联合多种免疫抑制剂治疗为主,但疗效并不理想,有许多患者使用该类药物治疗副作用严重。中医药则侧重于整体调节,对于重建免疫功能自稳状态有良好的作用,协同应用还可减少激素的副作用、增强临床疗效,有广阔的前景。
Systemic lupus erythematosus(SLE) is an autoimmune disease characterized by production of auto-antibodies against different auto-antigens, and systemic inflammatory reaction. Despite the improved treatment over the past decades, glucocorticoids remain as a first line medicine. Considering the significant morbidity derived from drug complications, new therapeutic strategy for SLE is urgently needed. This review offers a general overview of developing a traditional Chinese medicine (TCM) based method in SLE treatment. A systemic regulated immunological function, a blockage of inflammation signal pathways, a diminished severe side effect by glucocorticoids, and a significant improved long-term survival and quality of life all appears to be bright attractive points of this newly proposed therapeutic strategy.
出处
《上海中医药大学学报》
CAS
2007年第2期73-76,共4页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
国家教育部重点科研基金资助项目(05ZZ11)
上海市教委基金资助项目(05Jg05053)
上海市科委基础研究重点资助项目(05JC14056)
上海高校一氧化氮与炎症医学E-研究院计划项目(E-04010)
上海中医药大学科研资助项目
关键词
系统性红斑狼疮
细胞因子
炎症
中医药
Systemic lupus erythematosus (SLE)
cytokine
inflammation
traditional Chinese medicine