新生儿高间接胆红素血症77例病因探讨

Causes of neonatal unconjugated hyperbilirubinemia:Report of 77 cases

目的:探讨新生儿高间接胆红素血症(简称高胆)的病因及预防措施.方法:对77例高胆的病因进行分析,对不同病因引起的高胆采取相应的治疗.结果:病因依次为感染因素53例次,围生因素24例次,母乳性黄疸11例次,新生儿溶血病3例次.同一高胆患儿可存在2～3种致病因素,多因素发生率为16.88%.预后较好,77例中痊愈64例,好转12例,放弃治疗1例.结论:做好围生期保健对预防新生儿高胆,降低其发病率有重要意义.

Objective:To explore the causes and preventive measures for neonatal unconjugated hyperbilirubinemia.Methods:The causes of neonatal unconjugated hyperbilirubinemia in 77 newborns(51 male and 26 female) were analyzed.Active treatments were given according to the causes.Results:The causes of neonatal unconjugated hyperbilirubinemia included infectious factors(58.24%),perinatal factors(26.37%),breast-feeding jaundice(12.09%) and hemolytic disease of the newborn(3.30%).The infectious factors were the most common causes for unconjugated hyperbilirubinemia in the newborns.However,several causes leading to hyperbilirubinemia might exist in the same newborn.In this study,16.88% cases of hyperbilirubinemia were induced by more than one causes.Prognosis is good.Among the 77 cases,64 cases were cured,12 cases improved,and 1 case was given up.Conclusions:In order to reduce the incidence of neonatal unconjugated hyperbilirubinemia,more emphasis should be put on the health care of the perinatal period.