潮气呼吸肺功能测定鉴别诊断小儿慢性咳嗽的价值

Tidal breathing lung function in diagnosis of chronic cough in children

目的:探讨慢性咳嗽患儿的重要肺功能参数特点以及临床应用价值。方法:对68例6岁以下慢性咳嗽患儿按非哮喘组和咳嗽变异性哮喘(CVA)组进行潮气呼吸肺功能检测,并与典型哮喘患儿的肺功能比较。结果:慢性咳嗽非哮喘组与CVA组潮气量(VT)、呼吸频率(RR)和呼气时间(TE)差异均无统计学意义(P>0.05),吸气时间(TI)、吸呼比(TI/TE)、达峰时间比(TPF/TE)和达峰容积比(VPF/VE)差异均有统计学意义(P<0.05)。慢性咳嗽非哮喘组TPF/TE和VPF/VE均明显高于CVA组(P<0.01),两组其余各指标均无统计学意义(P>0.05)。CVA组患儿TI/TE高于哮喘组(P<0.05),两组其余各指标差异均无统计学意义(P>0.05)。结论:肺功能测定对慢性咳嗽的非哮喘和CVA患儿鉴别诊断有重要意义,为指导临床治疗提供循证医学依据。

Objective:To study the parameter features of lung function in children with chronic cough and its clinical value.Methods:Sixty-eight children(under 6 years of age) with chronic cough including 33 cases of non-asthma and 35 cases of variant asthma(CVA)were detected of the tidal breathing pulmonary function,and the result was compared with that of other 38 cases of typical asthma.Results:There was no difference between non-asthma group and CVA group in the following parameters:tidal volume(VT),rate of respiratory(RR) and time of expiration(TE)(P>0.05);meanwhile,the time of inspiration(TI),time of inspiration/time of expiration(TI/TE),time to peak expiratory flow/time of expiration(TPF/TE),and volume of peak expiratory flow/volume of expiration(VPF/VE) demonstrated significant difference(P<0.05) between the two groups.TPF/TE and VPF/VE in the non-asthma group was obviously higher than that in the CVA group and the other parameters had no statistical significance(P>0.05).Ratio of TI/TE in CVA group was higher than that in typical asthma group(P<0.05),but the difference was not significant between them with other parameters(P>0.05).Conclusions:Lung function test has great value in distinguishing patients with chronic cough with non-asthma and those with cough variant asthma,which may provide clinical basis for the treatment of the disesase.