摘要
用荧光法测定了45例视网膜色素变性(RP)及21例正常对照血小板内丙二醛(MDA)及血小板被乙酰琥珀酸亚胺(NEM)激活前后MDA比值(MDA/MDAa),结果显示RPMDA(0.8308±0.2674nM/10~9血小板)较正常对照(0.5919±0.2430)升高,RPMDA/MDAa(0.22824±0.0609)亦较正常对照(0.1580±0.0541)升高,且均具有统计学意义(P<0.01),提示RP脂质过氧化代谢增强,血液凝固性增高,还讨论了MDA及MDA/MDAa升高在RP致病机理中的意义及抗脂质过氧化药物、抗凝剂在RP治疗中联合使用的必要性。
With fluorimetry, the concentration of malondialdehyde (MDA) and the ratio of MDA before and after the blood platelets activated (MDA/MDAa) were determined in patients with retinitis pigmentosa (RP). The results showed the above two parameters were statistically higher than those of the normal controls, which indicated the superoxidation metabolism increased and the blood was in a state of hypercoagulation in RP patients. The reasons for the results and their roles in RP disease were discussed. Treatments w...
出处
《眼科学报》
1994年第4期224-226,196,共4页
Eye Science
