摘要
蒲黄及提取物总黄酮、有机酸、多糖对花生四烯酸诱导兔体内外血小板聚集功能具有明显的抑制作用,抑制最大聚集%的作用强度依次为:总黄酮>多糖>煎液>有机酸;抑制聚集坡度的作用强度为:总黄酮>煎液>多糖>有机酸;说明黄酮类物质可能是蒲黄抗血小板聚集的主要有效成分,同时表明这些药物对血小板最大聚集%和坡度的作用是有差别的。
Typha angustifocia L(TA ) and its extracts: total flavones ( FT ) , organic acids ( OT ) , and poly saccharide ( PT ) inhibited platelet-aggregation induced by arachidonic acid in rabbits significantly and dose-dependend in vitro. The IC50-m of TA, FT, OT and PT for maximum aggregation % was 9.3, 3.0, 12.1, and 6.5g/L PRP and IC50-s for aggregating slope was 10.8, 4.3, 17.7 and 15.3 g/L PRP respectively. The ratio of IC50-m/IC50-s was TA 1 : 1.2, FT 1 : 1.4, OT 1 : 1.5, and PT I : 2.4 respectively. FT and O...
出处
《中国药理学通报》
CAS
CSCD
北大核心
1990年第5期328-331,共4页
Chinese Pharmacological Bulletin
关键词
蒲黄
黄酮
有机酸
多糖
血小板聚集
聚集坡度
花生四烯酸
Typha angustifocia L
Flavone
Organic acid
Polysaccharide
Platelet aggregation
Platelet aggregation slope
Arachidonic acid
