O-甲基蝙蝠葛碱对麻醉犬ECG和血流动力学的影响

EFFECT OF O-METHYLDAURICINE ON ECG AND HAE-MODYNAMICS IN ANAESTHETIZED DOGS

OMD系Dau的衍生物。本实验研究OMD 2.5mg/kg iv对14只麻醉犬的ECG和血流动力学的影响。实验发现,OMD具有明显降低SBP和DBP的作用,随剂量增大作用加强。同时表现出TPR降低,SV增加和PEP/LVET轻度增大。这些与Dau的作用相似。还观察到HR减慢,MPAP和PCWP无明显改变。本品2.5mg/kg对ECG无明显影响,5mg/kg使PR轻度延长,QRS和QTc均无明显改变。该结果与Dau对ECG的影响有明显差异,已有报道后者在同等剂量时明显延长PR和QRS。

The effects of o-methyldauricine ( OMD ) , a derivative of dau-ricine, 2.5 & 5 nig/kg given intravenously on ECG & haemodyna-mics were studied in 14 anaesthetized dogs.OMD significantly decreased systolic & diastolic blood pressure dose-dependently, accompanied by a decrease in total peripheral resistance, an increase in strok volume & a slight increase in PEP/LVET. These haemodynamic effects are similar to those of dauricine. It produced a decrease in heart rate & no changes of mean pulmonary artery pressu...