摘要
用6种实验性心律失常动物模型,观察ZnSO_4的抗心律失常作用。ZnSO_4 iv10mg/kg能明显对抗乌头碱和BaCl_2诱发大鼠心律失常,显著缩短CHCl_3-肾上腺素引起家兔心律失常的持续时间.ZnS0_4ip20μg/10g可降低CHCl_3引起小鼠室颤率。但ZnSO_4不能降低CaCl_2引起大鼠室颤率,减少哇巴因引起室性早搏和心室颤动的阈剂量和致死量。
The antiarrhythmic actions of ZnSO4 (Zinc) were studied in ex-perimental arrhythmias models. ZnSO4 10mg/kg(iv) significantly coun-teracted the arrhythmias, induced by aconitine or BaCl2 rats.It was shown to shorten the duration of arrhythmias induced by chloroform-epinephrine in rabbits. In mice, ZnSO4 20 μg/10g(ip) decreased the incidence of ventricular fibrillationbychloroform. However, ZnSO4 did not decrease the incidence of CaCl2-induced , venticular fibrillation, the threshold and lethal doseofouabain ...
出处
《中国药理学通报》
CAS
CSCD
北大核心
1989年第2期101-103,共3页
Chinese Pharmacological Bulletin
基金
中国科学院科学基金资助的课题
