摘要
采用豚鼠离体乳头状肌和心房肌标本,观察了(COAMTA)对其生理特性的影响。结果表明COAMTA 10mg/L能明显延长功能性不应期,抑制肾上腺素诱发的自律性;但不降低兴奋性,对收缩性也无明显影响。提示COAM可能具有抗心律失常的作用。
Corydalis amabilis Migo total alkaloids (COAMTA) possessed antihypertensive and vaso-dilatative action in animal experiments. Its effects on the physiological properties in isolated guinea pig papillary muscles & atrium preparations were described in this papar. 10mg/L COAMTA markedly prolonged the functional refractory period(FRP) and inhibited epinephrine induced automaticity. Suppression of normal & abnormal automaticity and prolongation of FRP may contribute to the effectiveness of COAMTA on arrhythm...
出处
《中国药理学通报》
CAS
CSCD
北大核心
1989年第2期104-106,共3页
Chinese Pharmacological Bulletin
关键词
夏天无
心房肌
乳头状肌
心肌收缩
功能性不应期
自律性
Corydalis amabilis Migo
Heart atrium
Papillary muscles
Myocardial contraction
Functional refractory period
Au-tomaticity
