摘要
烟浪丁(NICO)对豚鼠乳头状肌的收缩力,有剂量依赖性抑制作用;降低乳头状肌的自律性,对其兴奋性和功能不应期(FRP)无明显影响。普萘洛尔和1.90mmol/L NICO,均使ISO量-效曲线平行右移,且心肌收缩力仍可达到给药前的最高水平,符合竞争性拮抗的特点。维拉帕米使CaCl_2量—效曲线非平行右移,最大收缩幅度明显降低;大剂量(3.80mmol/L)的NICO,亦使最大收缩幅度明显下降。
The effects of nicorandil ( NICO ) on the contractility, automati -city, excitability, functional refractory period ( FRP ) & dose-response curves for isoprenaline as well as calcium were studied in guinea pig papillary muscles. NICO could decrease the amplitude of contraction of papillary muscles dose-dependently. Propranolol and NICO might antagonize the inotropic effect of isoprenallne. Verapamil & NICO induced Ca2+ antagonistic effects in a non-competitive manner, & the maximal Ca2+ response of papillar...
出处
《中国药理学通报》
CAS
CSCD
北大核心
1989年第2期112-115,共4页
Chinese Pharmacological Bulletin
