沙棘总黄酮对小鼠免疫功能的影响

EFFECTS OF TOTAL FLAVONES OF HIPPOPHAE RHAM-NOIDES L (TFH) ON IMMUNOLOGICAL FUNCTION IN MICE

沙棘总黄酮(TFH)是沙棘有效成分。能增强小鼠特异和非特异免疫功能,对小鼠血清溶菌酶、吞噬功能、总补体含量,都有增强的作用;促进抗体生成,使血清抗体水平升高,并且增加免疫功能低下者的水平。血液T细胞比例和SRFC的脾细胞都增加,同时,ConA激活的淋巴细胞增殖增强。这些结果表明沙棘总黄酮有明显增强作用。

TFH was isolated from the fruits of Hippophae Rhamnoides L. A study was made cf the effects of TFH on the immune reaction in animals. TFH ( 5.0mg/kg· d-1 sc·6d)remarkably enhanced the pha-gocytic activity of peritoneal exudate macrophages. The content of lysozyme in mice ( TFH 2mg/kg·d-1 ip×7d) & serum complement in guinea pig also were remarkably elevated. TFH caused significant increases of quantitative hemolysin of SRBC ( QHS ) in normal mice. At the dose of 2mg/kg·d-1 ip×8d TFH increased the production ...