摘要
红芪多糖(RHPS)和黄芪多糖(APS)对正常小鼠和免疫抑制小鼠的免疫功能有影响.实验表明RHPS和APS均能增强小鼠腹腔巨噬细胞吞噬功能,并能完全纠正PDS的抑制作用;能促进体内淋巴细胞转化,并能使ANAE阳性淋巴细胞显著增多,对CY或PDS所致的细胞免疫功能低下有显著的纠正作用。家兔外周血淋巴细胞体外培养结果表明,RHPS或APS 1～100mg/L对PHA 50mg/L刺激淋巴细胞增生的作用无显著影响。RHPS对正常小鼠血浆cAMP水平无明显影响,但与PDS合用时可使血浆cAMP水平显著高出对照组和单用PDS组。
The effects of RHPS & APS on immune function in normal mice and immunosuppressed mice were studied. The results showed that RHPS and APS enhanced not only the phagocytosis of peritoneal mac-rophages in normal mice, but also antagonized completely the immun- Osuppresslve effect of prednisoione. RHPS and APS increased both the lymphocyte transformation rate induced by PHA and ANAE+ rate in normal mice, and antagonized also the suppressive effects of GY or PDS. No significant influence was found on the prolife...
出处
《中国药理学通报》
CAS
CSCD
北大核心
1989年第6期367-372,共6页
Chinese Pharmacological Bulletin
关键词
红芪
黄芪
多糖
巨噬细胞
淋巴细胞
CAMP
Radix Hedysari
Astragalus membranaceus
Polysaccha-ride
Phagocytosis
Lymphocyte
cAMP
