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RD抗涎腺腺样囊性癌细胞转移的体外实验研究 被引量：3

Antimetastatic effects of arginine-aspartate on salivary adenoid cystic carcinoma in vitro
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摘要 目的　研究精氨酸 天冬氨酸 (RD)抗涎腺腺样囊性癌 (salivaryadenoidcysticcarcinoma ,SACC)转移的作用。方法　MTT法测定RD对SACC LM与纤维粘连蛋白、层粘连蛋白、Ⅳ型胶原粘连的影响 ,用改良Boydenchamber方法观察RD对SACC细胞人工重组基底膜侵袭以及趋化运动能力的作用。结果　RD在 5mg/L时能抑制SACC LM与细胞及纤维粘连蛋白的粘附 ,而对SACC LM与层粘连蛋白、Ⅳ型胶原的粘附无明显作用。RD在 1、5、2 5mg/L时能明显抑制SACC LM对人工基底膜的侵袭。RD在2 5mg/L时能抑制SACC LM的趋化运动。 Objective To test the effects of arginine aspartate (RD) on metastasis of salivary cystic carcinoma (SACC). Methods Hightly metastatic SACC cell line SACC LM was used in the study. The effect of RD on tumor cell ECM adhesion was assayed by MTT technique. The effect of RD on invasion and migration of SACC LM were evaluated using modified boyden chamber. Results RD inhibited tumor cell fibronectin adhesion at 5 mg/L concentration, but no effects on tumor cell laminin and tumor cell type Ⅳ collagen adhe...
作者 李凤和 俞光岩 彭师奇 李盛琳 武登诚 傅嘉
机构地区 北京大学口腔医学院口腔颌面外科 北京大学药学院
出处 《中华口腔医学杂志》 CAS CSCD 北大核心 2001年第6期67-69,共3页 Chinese Journal of Stomatology
基金 国家自然科学基金资助项目 ( 392 70 72 3)
关键词 涎腺 癌 腺样囊性 肿瘤转移 Salivary glands Carcinoma adenoid cystic Neoplasm metastasis
分类号 R739.87 [医药卫生—肿瘤]
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参考文献7

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同被引文献43

  • 1王玲,王振义,戚正武.纤维粘连蛋白的分子生物学研究[J].生物化学与生物物理进展,1994,21(2):109-112. 被引量：4
  • 2蒋凯,吴士明.三羟异黄酮对光动力疗法中H22细胞VEGF表达的影响[J].激光杂志,2005,26(2):88-89. 被引量：1
  • 3余小平,糜漫天,朱俊东.木黄酮对MCF-7/HER-2细胞uPA表达影响[J].中国公共卫生,2006,22(8):937-939. 被引量：4
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中华口腔医学杂志
2001年 第6期

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