灯盏花素联合氯沙坦治疗糖尿病肾病的临床观察

Clinical Observation on Breviscapin Combined with Cozaar for Diabetic Nephropathy

目的观察灯盏花素注射液联合氯沙坦对糖尿病肾病的疗效。方法80例糖尿病肾病患者随机分为对照组与治疗组,对照组给予糖尿病常规治疗方案+氯沙坦,治疗组在对照组用药基础上加用灯盏花素注射液,观察2组疗效及对24h尿蛋白排泄率(UPE)、血尿素氮(BUN)、血清肌酐(Scr)、尿β2-微球蛋白(β2-MG)的影响。结果与对照组比较,治疗组可使UPE、BUN、Scr显著下降,尿β2-MG明显改善(P<0.05或P<0.01);治疗组与对照组有效率分别为85%、70%(P<0.05)。结论灯盏花素注射液联合氯沙坦对减轻糖尿病肾病蛋白尿有明显疗效,从而延缓肾小球硬化进程。

OBJECTIVE:To investigate the efficacy of breviscapin injection in combination with cozaar for diabetic nephropathy.METHODS:80patients with diabetic nephropathy were randomly divided into two groups:the control group was treated with conventional therapy for diabetes plus cozaar(50mg/d);the treatment group(TG)was treated with breviscapine injection and cozaar in addition to the conventional therapy for diabetes.The curative effects of two groups and levels of24h urine protein excretion(UPE),blood urea nitrog...