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姜黄素-羟丙基-β-环糊精包合物的制备及其理化性质研究 被引量：17

Studies on Preparation and Physicochemical Properties of Inclusion Complex of Curcumin with HP-β-Cyclodextrin
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摘要 目的:制备姜黄素-羟丙基-β-环糊精包合物并考察其理化性质。方法:采用冷冻干燥法制备姜黄素-羟丙基-β-环糊精包合物,对其进行鉴别并考察其包合率、稳定性及水溶性等。结果:包合物冻干粉经鉴别已形成包合物,包合率为96·58%,姜黄素的稳定性及水溶性均得到改善。结论:所制包合物能显著增加药物在水中的溶解度,提高药物的稳定性。 OBJECTIVE: To prepare the inclusion complex curcumin-hydroxypropyl-β -cyclodextrin (CUR-HP-β-CD) and study its physicochemical properties. METHODS: The inclusion complex of curcumin with HP-β-cyclodextrin (HP-β-CD) was prepared by freeze-drying method, and its inclusion rate, stability and water solubility were identified and examined by UV and X-ray powder diffractometry. RESULTS: The identification showed that the freeze-dried powder developed into an inclusion complex, with an inclusion rate of 96.58%. T...
作者 高振珅 王兰
机构地区 陕西科技大学生命科学与工程学院
出处 《中国药房》 CAS CSCD 北大核心 2007年第13期999-1000,共2页 China Pharmacy
基金 咸阳市科技局资助项目(K050124) 陕西科技大学研究生创新基金资助项目(yc056)
关键词 姜黄素 羟丙基-Β-环糊精 包合物 制备 稳定性 水溶性 Curcumin HP-β-cyclodextrin Inclusion complex Preparation Stability Water-solubility
分类号 TQ461 [化学工程—制药化工]
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中国药房
2007年 第13期

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