吲哚美辛脂质体滴眼液在家兔眼内的药动学

Study on the pharmacokinetics of indomethacin ophthalmic liposomal solution in the rebbit eye

目的:研究吲哚美辛脂质体滴眼液在家兔眼内的药动学过程,为临床应用提供依据和参考。方法:以市售吲哚美辛滴眼液 为参比制剂,采用高效液相色谱法(HPLC)测定两种制剂在用药后不同时间家兔房水中的药物浓度,按单剂量方案进行研究并计算 药动学参数。结果:两药在家兔眼内均为一室模型,受试药物主要药动学参数为:Tmax=0.2045h;Cmax=1.5187mg·L-1:AUC= 1.9817mg·L-1·h。参比药物为:Cmax=0.3881mg·L-1,Tmax=0.7981h,AUC=0.8585mg·L-1·h。结论:与吲哚美辛滴眼液相 比吲哚美辛脂质体滴眼液眼内生物利用度提高2.3倍。

OBJECTIVE To study the pharmacokinetics of indomethacin ophthalmic liposomal solution(IOLS ) in rabbit eye. METHODS A HPLC was developed for determination of indomethacin in the aqueous humor rabb it eye at differenent time point. Pharmacokinetics and bioavailability study were compared with IOLS and indomethacin ophthalmic solution(IOS). RESULTS The aqueous humor concentration time data showed a one- compartment model. T he important parameters of IOLS and IOS in rabbit aqueous humor average equati...