双歧三联活菌辅助治疗肝硬化肠源性内毒素血症

The effect of bifid triple viable to endotoxemia and some cytokines of liver cirrhosis patients

目的:探讨常规保肝治疗基础上辅助应用双歧三联活菌制剂对肝硬化内毒素血症的疗效。方法:选择肝硬化患者60例, 随机分为对照组和实验组。应用鲎试剂动态比浊法测定血浆中内毒素的含量;应用酶联免疫技术测定血浆中IL 1α、IL 6、TNFα的 含量,并进行比较分析。结果:实验组治疗后与治疗前相比,各观察指标的含量均明显降低(P<0.05);对照组治疗前后血浆中各观 察指标的含量差异无显著性;实验组血浆中各观察指标的含量均比对照组低(P<0.05)。结论:口服双歧三联活菌制剂可以明显降 低血浆中内毒素的水平,减少生物活性介质IL 1α、IL 6和TNFα的释放,促使肝功能好转。

OBJECTIVE To investigate the clinical significance of Bifid Triple Viable that was used to treat endotoxemia of Liver cirrhosis on the base of general therapy, and to obs erve the change of endotoxin and some cytokines (IL-1α, IL-6, TNFα) in plasm a during the treatment.METHODS 60 hospitalizing patients with liver cirrhosis were included in the study. The p atients satisfied the conditions were separated into two groups at random. One w as control group, another was BTV group. The plasma was separated to...