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注射用紫杉醇的制备及过敏试验 被引量：3

Preparation of pactilaxel for injection and its hypersusceptibility test
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摘要 　目的:通过增溶法优化紫杉醇冻干注射剂处方,并进行过敏性试验。方法:以羟丙基 β 环糊精和聚乙二醇1500作增溶剂, 冷冻干燥法制备紫杉醇冻干注射剂,并以泰素(Taxol)为对照,对两种剂型进行了过敏试验比较。结果:紫杉醇冻干注射剂在生理 盐水中较稳定;豚鼠过敏性明显地低于泰素。结论:羟丙基 β 环糊精和PEG作为紫杉醇冻干注射剂的增溶剂,可有效降低过敏反 应发生率和提高安全性。 OBJECTIVE To optimize the prescription of lyophilized paclitaxel for injection and to co nduct, hypersusceptibility test.METHODS The injection was prepared by lyophilization with the hydropropyl-β-cyclode xtrin and polyethylene glycol(PEG) 1 500 as solubilizing agent. Taxol was us ed as control drug, the hypersusceptibility of the injection was tested with gu inea pig. RESULTS Lyophilized paclitaxel for injection was stabile in 0.9% sodium chloride in jection. Incidence of hypersusceptibilit...
作者 张学农 唐丽华 阎雪莹 张强
机构地区 苏州大学药学系 黑龙江中医药大学 北京大学药学院药剂系
出处 《中国医院药学杂志》 CAS CSCD 北大核心 2005年第1期35-37,共3页 Chinese Journal of Hospital Pharmacy
关键词 紫杉醇 注射剂 过敏反应 paclitaxel injection hypersusceptibility
分类号 R944.9 [医药卫生—药剂学]
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参考文献5

  • 1[1]Loprevitr M, Roberto EF, Alessandra DC, et al. Interaction between novel anticancer and radiaton inno-small cell lung cancer cell lines[J]. Llung Cancer, 2001,33:27.
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  • 3张学农,张强.紫杉烷类新剂型的研究进展及其临床应用[J].国外医学（药学分册）,2002,29(6):321-325. 被引量：25
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二级参考文献26

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共引文献24

同被引文献35

引证文献3

二级引证文献16

中国医院药学杂志
2005年 第1期

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