摘要
目的:通过增溶法优化紫杉醇冻干注射剂处方,并进行过敏性试验。方法:以羟丙基 β 环糊精和聚乙二醇1500作增溶剂, 冷冻干燥法制备紫杉醇冻干注射剂,并以泰素(Taxol)为对照,对两种剂型进行了过敏试验比较。结果:紫杉醇冻干注射剂在生理 盐水中较稳定;豚鼠过敏性明显地低于泰素。结论:羟丙基 β 环糊精和PEG作为紫杉醇冻干注射剂的增溶剂,可有效降低过敏反 应发生率和提高安全性。
OBJECTIVE To optimize the prescription of lyophilized paclitaxel for injection and to co nduct, hypersusceptibility test.METHODS The injection was prepared by lyophilization with the hydropropyl-β-cyclode xtrin and polyethylene glycol(PEG) 1 500 as solubilizing agent. Taxol was us ed as control drug, the hypersusceptibility of the injection was tested with gu inea pig. RESULTS Lyophilized paclitaxel for injection was stabile in 0.9% sodium chloride in jection. Incidence of hypersusceptibilit...
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2005年第1期35-37,共3页
Chinese Journal of Hospital Pharmacy
关键词
紫杉醇
注射剂
过敏反应
paclitaxel
injection
hypersusceptibility