鼎突多刺蚁对免疫功能的影响

The Effects of Pofyrhachis vicina on Immunoregulation in Mice

目的:研究鼎突多刺蚁对免疫应答的调节作用。方法:通过测定正常小鼠和免疫功能异常小鼠给药后的免疫功能指标考察鼎突多刺蚁对小鼠免疫功能的调节作用。结果:鼎突多刺蚁(0.25g·kg^(-1)·d^(-1)×10d、0.5g·kg^(-1)·d^(-1)×10d、1.5g·kg^(-1)·d^(-1)×10d)给小鼠口服,对正常小鼠的非特异性免疫(免疫器官的重量)及细胞免疫(迟发型超敏反应,DTH)均无明显作用;在利用氢化可的松(ig.5×10^(-2)g·kg^(-1)·d^(-1)×5d.)诱导免疫低下后,同样剂量给药,对免疫低下小鼠的体液免疫(溶血素测定法)、非特异性免疫(碳廓清法)均有不同程度的恢复作用;对于用环磷酰胺(Cy)诱导的免疫亢进(ig.250g·kg^(-1)·d^(-1)×10d)及低下(ig.80mg·kg^(-1)·d^(-1)×1d)小鼠,鼎突多刺蚁(1.5g·kg^(-1)·d^(-1)×10d)能调整其异常的细胞免疫(DTH)。结论:鼎突多刺蚁具有免疫调节作用。

Objective:To study the immuno-regulatory effects of Polyrhachis vicina Roger(PVR) in mice. Method: By determining the immune function of normal mice and immune function-depressed or enhanced mice after the administration of PVR. Results: PVR (0.2Sg·kg-1·d-1×10 d,0.5 g·kg-1·d-1×10 d,1.5 g·kg-1·d-1×10 d, op)had no effects on non-specific immune function (weight of immune organs) and cell immune function (delayed type hypersensitivity, DTH) in normal mice, but could improve the non-specific immune function and...