(3S)-2,2-二甲基-3-苄氧基癸酸的合成

Synthesis of (3S)-3-Benzyloxy-2,2-dimethyl-decanoic Acid

以 (R) pantolactone为原料 ,经还原、羟基保护、环合、开环、脱保护、氧化等 8步反应 ,合成了 (3S) 2 ,2 二甲基 3 苄氧基癸酸 ,总收率为 40 0 % .

(3S)-3-Benzyloxy-2,2-dimethyl-decanoic acid was synthesized from (R)-pantolactone through reduction, hydroxy protection, cyclization, ring-opening, de-protection, oxidation, et al. in overall yield of 40.0%.