相转移催化 Reimer-Tiemann 反应合成羟基苯甲醛类

HYDROXYBENZALDEHYDES SYNTHESIZED BY PHASE TRANSFER CATALYST REIMERTIEMANN REACTION

用经典的ＲｅｉｍｅｒＴｉｅｍａｎｎ反应合成二甲基羟基苯甲醛和二羟基苯甲醛时产率（１０％以下）很低。我们研究了以三丁胺为相转移催化剂，用甲醇和水作反应介质，对ＲｅｉｍｅｒＴｉｅｍａｎｎ反应进行了改进，使产率（２１．０％～５２．１％）有明显提高。

The synthetic yield of dimethyl hydroxybenzaldehyde and three dihydroxybenzaldehydes, via classical ReimerTiemann reaction, is generally very low (less 10%). We used tributyl amine as the phasetransfer catalyst, methanol and water as reaction medium to improve the ReimerTiemann reaction, which obviously increased the yield (21.0%～52.1%).