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云南美登木内生真菌Chaetomium globosum Ly50′菌株的抗菌活性成分研究 被引量：18

Antimicrobial Components of the Endophytic Fungal Strain Chaetomium globosum Ly50′ from Maytenus hookeri
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摘要 从云南美登木叶中分离筛选到具抗菌活性的内生真菌Chaetomium globosum Ly50′菌株,利用活性追踪法在其发酵产物中分离到抗橙色青霉和抗结核分枝杆菌的化合物,经ESI-MS、NMR等波谱数据确认该活性成分为球毛壳甲素,chaetoglobosin A和球毛壳乙素chaetoglobosin B。首次发现chaetoglobosin B具有抗结核分支杆菌活性。 The fungal strain Chaetomium globosum Ly50′ was isolated from the leaf of Maytenus hookeri and was active against Penicilium avellaneum UC-4376 and Mycobacterium tuberculosis.Activity-guided isolation led two compounds from the secondary metabolites.They were determined to be chaetoglobosin B (1) and chaetoglobosin A (2) on the basis of spectroscopic analysis.Chaetoglobosin B possesses obvious antituberculosis activity.
作者 倪志伟 李国红 赵沛基 沈月毛
机构地区 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室
出处 《天然产物研究与开发》 CAS CSCD 2008年第1期33-36,共4页 Natural Product Research and Development
基金 国家杰出青年基金项目(30325044) 国家自然科学基金项目(30430020)
关键词 内生真菌 云南美登木 球毛壳菌 chaetoglobosin A chaetoglobosin B endophytic fungi Maytenus hookeri Chaetomium globosum chaetoglobosin A chaetoglobosin B
分类号 R915 [医药卫生—微生物与生化药学]
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参考文献12

  • 1[1]Fisher PJ,Pctrini O,Scott HML.The distribution of some fungal and bacterial endophytes in maize (Zea mays L.).New Phytol,1992,122:299-305.
  • 2[2]Strobel G,Daisy B,Castillo U,et al.Natural products from endophytic microorganisms.J Nat Prod,2004,67:257-268.
  • 3[4]Wei JC(魏景超).Fungi Identification Manual(真菌鉴定手册).Shanghai:Shanghai Scientific & Technical Publishers,1979,196-197.
  • 4[5]Zhang LQ(张玲琪),Wang HK(王海昆),Shao H(邵华),et al.Isolation and determination of the anti-cancer substance of chaetoglobosin A producing by endophytic fungus of in Maytenus hookeri.Chin Pharm J(中国药学杂志),2002,37:172-175.
  • 5[6]Zhao PJ,Li GH,Shen YM.New chemical constituents from the endophyte streptomyces species LR4612 cultivated on Maytenus hookeri.Chem Biodivers,2006,3:337-342.
  • 6[7]Espinel-Ingroff A,White T,Pfaller MA.Antifungal agents and susceptibility tests,In:Manual of Clinical Microbiology,7th Ed.(Murray PR ed.),American Society for Microbiology,Washington DC,1999.1640-1652.
  • 7[8]Sekita S,Yoshihira K,Natori S,et al.Chaetoglobosis,cytotoxic 10-(Indo-3-yl)-[13]cytochalasans form Chaetomium spp.IV 13C-nuclear magnetic resonance spectra and their application to a biosynthetic study.Chem Pharm Bull,1983,31:490-498.
  • 8[9]Sekita S,Yoshihira K,Natori S.Structure of chaetoglobosin A and B,cytotoxic metabolites of Chaetomium globosum.Tetrahedron lett,1973,14:2109-2112.
  • 9[10]Loh J,Pierson EA,Pierson LS,et al.Quorum sensing in plant-associated bacteria.Curr Opin Plant Biol,2002,5:285-290.
  • 10[11]Tan RX,Zou WX.Endophytes:a rich source of functional metabolites.Nat Prod Rep,2001,18:448-459.

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天然产物研究与开发
2008年 第1期

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