白花败酱抗炎作用化学成分研究

Studies on Anti-inflammation Chemical Constitutes of Patrinia villosa

目的:对败酱科植物白花败酱Patrinia villosa(Thunb.)Juss.抗炎有效成分进行分离和鉴定。方法:采用多种柱色谱方法进行分离纯化,根据光谱数据和理化性质鉴定化合物的结构。结果与结论:从白花败酱乙酸乙酯和正丁醇部位中分离得9个化合物,目前鉴定出7个,分别为:β-谷甾醇(β-sitosterol)(Ⅰ)、白花败酱醇(Villosol)(Ⅱ)、槲皮素(Quercetin)(Ⅲ)、阿魏酸(Ferulic acid)(Ⅳ)、熊果酸(Ursolic acid)(Ⅴ)、β-胡萝卜苷(β-daucosterol)(Ⅵ)和芦丁(Rutin)(Ⅶ)。其中化合物Ⅳ、Ⅴ和Ⅶ是首次从该种植物中分离得到。

Patrinia villosa(Thunb.) Juss.is a Chinese folk medicine,in order to find the material basis that were related to antiinflammation pharmacodynamic action, we investigated for chemical constituents by chemical and spectroscopic analysis.By phytochemical research,9 compounds were isolated from the acetic acid ethyl ester & N-Butanol of P.villosa and identified 7 compounds(β-sitosterol, Villosol,Quercetin,Ferulic acid,Ursolic acid,β-daucosterol,Rutin),and three compounds(Ferulic acid,Ursolic acid and Rutin) ar...